Protein Scientist - Chemical Biology

Requisition ID: RES002052

The Merck Research Laboratories (MRL) Exploratory Science Center (ESC) Cambridge, a wholly owned subsidiary of Merck and Co., is focused on driving early discovery research. Co-located with Merck’s Cambridge Innovation Hub, the ESC’s disease-area-agnostic research agenda fosters hands-on collaboration between our scientists and external academic and biotech researchers to access and explore the most promising emerging science.    Our ability to excel depends on the integrity, knowledge, imagination, skill, diversity and teamwork of an individual like you.  To this end, we strive to create a fast-paced, nimble and flexible environment of mutual respect, creativity, invention and teamwork.  With access to Merck’s proven global R&D organization, you’ll have the opportunity to collaborate with talented and dedicated colleagues while developing and expanding your career. We are seeking an innovative and experienced protein scientist to join the Merck Exploratory Science Center (MESC) in Cambridge, MA. The successful candidate will become part of a lab-based, creative and fast-paced team that will discover novel biology and invent impactful technologies targeting these areas:
  1. Interaction between the microbiome and human cells/tissue, including the immune system
  2. Host-pathogen interactions in important infectious diseases
  3. Approaches that will impact other key areas of focus within Merck, such as oncology, inflammation, cardiovascular, metabolism, and neuroscience
This is a lab-based position and an excellent opportunity for someone seeking scientific and career growth in a multidisciplinary area of drug discovery. Your personal growth and career development will contribute to the success of our team. Responsibilities include and are not limited to the following:
  • Manage the maintenance and daily operation of a Thermo LC and Q-Exactive HF Orbitrap
  • Develop and execute nanoflow LC-MS/MS workflows for discovery proteomics focused on identifying and characterizing novel protein-protein and protein-ligand interactions
  • Investigating potential therapeutic targets by designing and performing biochemical and cellular experiments that will be analyzed using LC-MS/MS
  • Characterizing protein bioconjugates to determine labeling ratios and identify sites of conjugation, such as Drug-to-Antibody Ratio (DAR) Calculations for Antibody-Drug Conjugates (ADCs)
  • Protein-small molecule binding-site elucidation
  • Developing novel techniques and solutions to challenging scientific questions
  • The candidate will be part of a cross-functional team contributing to the strategic direction of research programs across multiple therapeutic modalities
  • Act as a leader from the bench, driving experimentation design and execution
  • Provide scientific mentoring and technical training of team members as appropriate
  • Ensure all laboratory safety protocols are followed


  • Required:  M.S. in Biochemistry, Protein Sciences, Chemical Biology, Biomedical Sciences or related discipline
Required Experience:
  • Minimum of (5) years Academic or Pharmaceutical industry experience
  • Independent experimental design and execution of experiments
  • Rigorous scientific thinking and effective written and oral communication skills
  • Broad technical experience using LC/MSMS proteomics
  • Familiar with protein sample preparation, various protein labelling technologies, QC analysis, data processing, statistical analysis tools and protein identification
  • Experience using Thermo Orbitrap instrument(s)
Preferred Experience:
  • Demonstrated critical thinking and trouble-shooting ability when handling challenging proteins such as aggregated protein, multicomponent complex, or membrane proteins
  • Targeted and quantitative bottom-up proteomics experience
  • Experience designing and performing biochemical and cellular experiments
  • Q Exactive LC-MS/MS experience
  • Experience with activity and affinity-based chemoproteomics
  • Experience with post-translation modifications (eg. Glycosylation, lipidation, etc)
  • Passionate about biomedical research and drug discovery
 Our employees are the key to our company’s success.  We demonstrate our commitment to our employees by offering a competitive and valuable rewards program.  Our Company’s benefits are designed to support the wide range of goals, needs and lifestyles of our employees, and many of the people that matter the most in their lives.  If you need an accommodation for the application process please email us at [email protected]  Merck & Co., Inc. Kenilworth, N.J., U.S.A. known as Merck in the United States and Canada, is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products.  Today, we are building a new kind of healthcare company – one that is ready to help create a healthier future for all of us.

Job: Research Science
Other Locations:
Employee Status: Regular
Number of Openings:
Shift (if applicable):
Hazardous Materials:
Company Trade Name: Merck
Full time
Cambridge, Massachusetts 02138, US