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Scientist I, Formulation Development (100% ONSITE)

Why Seres Therapeutics

Seres Therapeutics is a leading microbiome therapeutics platform company developing a novel class of multifunctional bacterial consortia that are designed to functionally interact with host cells and tissues to treat disease.OurSER-109 program achieved the first-ever positive pivotal clinical results for a targeted microbiome drug candidate and has obtained Breakthrough Therapy and Orphan Drug designations from the FDA. The SER-109 program is being advanced for the treatment of recurrent C. difficile infection and has potential to become a first-in-class FDA-approved microbiome therapeutic.

Seres Therapeutics is a member of the Flagship Pioneering family of companies.

Position Summary

We are seeking a highly motivated Scientist to assist in formulation development for microbiome therapeutics. The scientist will design and develop novel, oral formulations intended to maximize the efficiency of live biologics to the GI tract. For this multidisciplinary role, the scientist will work with a creative, collaborative team of motivated scientists in pharmaceutical science, bioprocess development, analytical development, immunology, microbiology, and microbiome research. Responsibilities will include formulation screening (oral suspensions and dry powders), formulation development (QbD), process development (lyophilization, milling, blending), process ranging studies and analytical characterization (light scattering, SEM, density measurements, flow analysis, dissolution, disintegration, sedimentation time, rheology). The position will also work with manufacturers to perform feasibility assessments of innovative unit operations and novel enteric technologies.

What You'll Do

  • Development and physicochemical characterization of oral suspension and dry powder formulations
  • Development of small-scale in vitro screening techniques to predict formulation performance
  • Independent experimental design (DoE), execution, and troubleshooting
  • Process ranging studies to suppor, scale-up and process transfer
  • Feasibility assessments of new process technologies
  • Effective collaboration on a multidisciplinary team
  • Data analysis and written and oral presentation of results
  • Contribution to a safe and compliant laboratory work environment

The candidate must be a strong team player with excellent communication skills working in a complex cross-functional matrix. The candidate must be able to work independently and take initiative. The candidate must be intellectually curious and show resilience in solving complex problems. This candidate will show the courage to take risks and follow through to completion.

What You'll Bring

  • Experience in formulation development and advanced drug delivery technologies, with an emphasis on oral suspension and dry powder dosage forms
  • Experience with powder handling unit operations (lyophilization, milling, blending)
  • Strong analytical skills and experience in physicochemical characterization techniques such as light scattering, SEM, density measurements, flow analysis, dissolution, disintegration, sedimentation time, rheology
  • Understanding of oral absorption and GI physiology in humans and relevant preclinical species
  • Superior verbal & written communication skills
  • An excellent record of academic achievement, including publications in peer-reviewed journals
  • Strong personal character and ethics
  • Education Minimum Requirement:

    • PhD in pharmaceutical science, chemical engineering, biological engineering, biochemistry, or related field. Recent graduate with 0-2 years of industry experience.

You May Also Bring

  • Good working knowledge in the field of microbiology
  • Development of delayed release dosage forms
  • Design of Experiments (JMP)
  • Hands-on experience in microbiology or biochemistry

Candidates should be aware that Seres Therapeutics currently maintains a policy requiring all US-based employees to be fully vaccinated against COVID-19. Newly hired employees must be vaccinated prior to their employment start date.

Seres is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation, or any characteristic protected under applicable law.


Cambridge, MA, 02139, US