Intern, Bioinformatics (Summer 2023)

Intern, Bioinformatics (Summer 2023)

Bristol Myers Squibb | Christiana, DE, 19702, US
Salary Range:$31,000 – $38,000 Salary range estimated by Zippia

Posted 20 days ago

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At Bristol Myers Squibb, we are inspired by a single vision – transforming patients’ lives through science. In oncology, hematology, immunology and cardiovascular disease – and one of the most diverse and promising pipelines in the industry – each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

Position Summary

We are seeking a highly motivated student to join our group for a 10-week long summer internship program. A successful candidate will work with their mentor to create an ensemble of machine learning approaches to accurately identify short tandem repeats (STR) in the genome of patients. STRs have a recognized role in several phenotypes including amyotrophic lateral sclerosis (ALS), Huntington’s disease, myotonic dystrophies, etc. Multiple computational approaches exist that report the presence of pre-determined STRs in specific genomic loci. However, these computational approaches do not reach a perfect consensus of the set of the reported STRs on the same Next Generation Sequencing and Genome Wide Sequencing data. To fill this gap, the candidate will leverage published scientific literature to generate a set of well supported STRs and implement predictive approaches to construct an ensemble for detecting STRs. Further, the candidate will also explore the validity of the approach with business relevant cohorts. The candidate will have the opportunity to work with an interdisciplinary team of experienced bioinformaticians, collaborate with biologists and learn about the complexity of drug target discovery.

Key Responsibilities

  • Participate in designing a set of verified ground truth from published scientific literature that will assist in the construction of predictive approaches for detecting genomic expansions
  • Explore a range of features that could be useful in detecting correct genomic expansions reported by multiple computational tools
  • Construct an ensemble of predictive algorithms to detect genomic expansions with higher confidence

  • Build disease specific and patient specific set of STRs

  • Provide written documentation and specifications for developed methods and workflows
  • Expect to present to large audience at the completion of the internship
  • Qualifications & Experience

  • Currently enrolled in a graduate program in computer science, statistics, bioinformatics, life sciences or a similar field
  • Fluency with Linux, docker and AWS cloud computing
  • Experience with machine learning packages like scikit-learn

  • Experience with benchmarking predictive computational methods; familiarity with evaluation metrics

  • Good programming skills using scripting languages (e.g., Python, R/Bioconductor) and notebooks (e.g. R markdown, Jupyter notebook)
  • Experience with analyzing WGS data to explore genomic expansions is a plus
  • Excellent verbal and communication skills
  • Must be able to work full-time for the program duration
  • Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

    Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. 

    Physical presence at the BMS worksite or physical presence in the field is an essential job function of this role which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and enhances the Company culture.

    To protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation.  Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment.  This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S.

    Our company is committed to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an approval of accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application or if you are applying to a role based in the U.S. or Puerto Rico and you believe that you are unable to receive a COVID-19 vaccine due to a medical condition or sincerely held religious belief, during or any part of the recruitment process, please direct your inquiries to access our complete Equal Employment Opportunity statement.

    BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

    Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.