At Bristol Myers Squibb, we are inspired by a single vision – transforming patients’ lives through science. In oncology, hematology, immunology and cardiovascular disease – and one of the most diverse and promising pipelines in the industry – each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.
We are seeking a highly motivated student to join our group for a 10-week long summer internship program. A successful candidate will work with their mentor to create an ensemble of machine learning approaches to accurately identify short tandem repeats (STR) in the genome of patients. STRs have a recognized role in several phenotypes including amyotrophic lateral sclerosis (ALS), Huntington’s disease, myotonic dystrophies, etc. Multiple computational approaches exist that report the presence of pre-determined STRs in specific genomic loci. However, these computational approaches do not reach a perfect consensus of the set of the reported STRs on the same Next Generation Sequencing and Genome Wide Sequencing data. To fill this gap, the candidate will leverage published scientific literature to generate a set of well supported STRs and implement predictive approaches to construct an ensemble for detecting STRs. Further, the candidate will also explore the validity of the approach with business relevant cohorts. The candidate will have the opportunity to work with an interdisciplinary team of experienced bioinformaticians, collaborate with biologists and learn about the complexity of drug target discovery.
Construct an ensemble of predictive algorithms to detect genomic expansions with higher confidence
Build disease specific and patient specific set of STRs
Qualifications & Experience
Experience with machine learning packages like scikit-learn
Experience with benchmarking predictive computational methods; familiarity with evaluation metrics
Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.
Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.
Physical presence at the BMS worksite or physical presence in the field is an essential job function of this role which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and enhances the Company culture.
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