Scientist - Ocular Program

The Company

Dyno Therapeutics is reshaping the gene therapy landscape through AI-powered vectors. Through the application of our transformative technologies and strategic partnerships with leaders in gene therapy, we believe a future with life changing gene therapies for millions of people is within reach.

Our team includes world-class molecular and synthetic biologists, protein engineers and gene therapy scientists working alongside software engineers, data scientists, and machine learning experts. Dyno was named Startup of the Year in 2020 by Xconomy!

The Role

Scientist - Ocular Program Team. The Gene Therapy Group at Dyno applies technologies created by the Dyno platform to discover novel AAV capsids with the potential to improve gene therapies. The group is organized into Program Teams, each with a focus on improving delivery to a target tissue type. The Ocular Program is applying the Dyno platform toward improving AAV for delivery of gene therapies to diverse tissues and cell types within the eye. We are building a team of researchers motivated by an interest in eye biology and a drive to improve treatment options for ocular disorders leading to blindness. As a Scientist on the Ocular Program Team, you will support the Program as it advances through different functional areas of Dyno's platform. You will learn and integrate across the many disciplines represented within Dyno, including library design, computational biology, high-throughput library cloning, vector production, and tissue processing. You are expected to design and execute AAV screening and characterization experiments, and optimize engineering methods for application to the eye. You will actively collaborate with other wet lab and computational scientists, and will train and mentor junior staff members. While your primary focus will be in the eye, you will have opportunities to learn from and contribute to a diverse set of innovative scientific and cultural projects.

Responsibilities

  • Support in designing and managing functional program workflows in:
    • High throughput library cloning
    • Large scale viral vector production
    • Tissue processing and NGS based gene expression analyses 
  • Execute procedures and coordinate efforts with others to complete workflows
  • Compose relevant documentation, such as plans and timelines, process reports, progress updates, and SOPs
  • Optimize existing methods and implement new methods based on technical advances in the field
  • Collect, analyze, and present data from standard procedures and experiments
  • Train and supervise junior staff
  • Collaborate with colleagues across teams
  • Assist in lab organization, including ordering supplies, restocking, and sample tracking 
  • Follow lab protocols and safety regulations

Who you are

  • Experienced experimentalist
  • Quick and enthusiastic to learn
  • Respectful and supportive colleague
  • Good communicator
  • Thoughtful and detail oriented 
  • Excited to work in a dynamic and fast-paced environment

Basic qualifications

  • PhD in biology, biochemistry, biomedical engineering, or related fields
  • 5+ years hands-on wet lab experience
  • Ophthalmology and/or gene therapy research experience
  • Expertise and documented track record in at least two of the following areas:
    • High-throughput library cloning
    • Large scale viral vector production and purification
    • Tissue processing and quantification of gene expression
    • Single-cell sequencing
    • Next generation sequencing
  • Design of gene expression vectors
  • Experience in executing and generating standard operating procedures
  • Ability to document and maintain an organized account of lab work and results

Preferred qualifications

  • 1+ years of experience in biotech/pharma industry
  • Experience in protein engineering and/or computational analysis of high throughput data 
  • Experience in preclinical development
  • Experience working with automated sample processing and/or robotics
  • Experience with ELN/LIMS

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

Job Type: Full-time

Posted
10/02/2021
Salary Range
$67,000.00 - 107,000.00
per Year
Salary range estimated by
Location
Cambridge, MA 02140, US
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