Res Post Doc Fellow - mechanisms of epilepsy in novel experimental models

Req ID: 20982

Shift: Days

Employment Status: AF - Active - Regular - Full Time 

Job Summary


The laboratory of Ethan M. Goldberg ( at The Children’s Hospital of Philadelphia and The University of Pennsylvania, in Philadelphia, PA, U.S.A. is recruiting a postdoctoral fellow interested in studying mechanisms of epilepsy in novel experimental models. Our research interests and approaches include:

1. Study of epilepsy-associated ion channel variants expressed in heterologous systems, in neurons in culture, in acute brain slices, and in neurons derived from human induced pluripotent stem cells (iPSCs);

2. Treatment of epilepsy and modulation of cerebral cortical circuits in experimental models using GABAergic interneurons derived from mouse ES cells and human iPSCs;

3. Investigation of epilepsy mechanisms in acute brain slices in vitro and in awake, behaving experimental animals using cellular neurophysiology, EEG, optogenetics, and two-photon calcium imaging; 

The laboratory recently identified mutations in the gene SCN3A encoding the voltage-gated sodium channel Nav1.3 as a novel cause of very early onset epileptic encephalopathy (Zaman et al., 2018. Annals of Neurology. 83(4):703-717) and we are continuing to study this further using novel disease models. The laboratory has also made novel insights into pathomechanisms of Dravet syndrome (Favero et al. In press. J Neurosci).

There will be opportunities to develop new and exciting avenues of research at the intersection of cellular neurophysiology, inhibition, neural circuits, and disease, using a range of cutting-edge neuroscience techniques. The successful applicant should be a recent graduate with a Ph.D. in neuroscience or related/applied field (physiology, electrical or biomedical engineering, computer science). Prior experience with animal behavior, electrophysiology, imaging, and/or computational neuroscience, is preferred.

Interested individuals should send a brief cover letter, CV, and references and/or letters of recommendation to Dr. Goldberg at: The position will initially be for one year, with yearly extensions based upon satisfactory yearly review; salary is commensurate with experience and qualifications.

About the Employer
Dr. Goldberg is Assistant Professor in the Departments of Neurology and Neuroscience at The University of Pennsylvania and The Children’s Hospital of Philadelphia. The Children's Hospital of Philadelphia is an elite children’s hospital located on the CHOP/UPenn campus and has a long and distinguished tradition of research that has spanned nearly a century. The larger University of Pennsylvania neuroscience community is comprised of over 200 faculty with almost 100 neuroscience-related interest groups. 

Job Responsibilities

  1. Conduct independent scholarly research and develop new methods and protocols
  2. Participate in project planning, recording and evaluation of data
  3. Acquire technical, lab management and grant writing skills
  4. Participate in seminars, lectures, poster sessions and presentation at national meetings
  5. Supervise junior lab members
  6. Assist with other research projects

Required Education and Experience

  • A terminal degree PhD, MD, DVM, etc.
  • According to the CMS (Centers for Medicaid and Medicare Services) a copy of diploma or transcript is required as proof of academic achievement for all non-laboratory personnel performing non-waived POC testing

All CHOP employees who work in a patient building or who provide patient care are required to receive an annual influenza vaccine unless they are granted a medical or religious exemption.

Children's Hospital of Philadelphia is committed to providing a safe and healthy environment for its patients, family members, visitors and employees. In an effort to achieve this goal, employment at Children's Hospital of Philadelphia, other than for positions with regularly scheduled hours in New Jersey, is contingent upon an attestation that the job applicant does not use tobacco products or nicotine in any form and a negative nicotine screen (the latter occurs after a job offer).

Children's Hospital of Philadelphia is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability or protected veteran status.

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Talent Acquisition

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Philadelphia, PA 19146 

Phone: 866-820-9288